(2011). If pharma practices the five skills of questioning, observing, networking, experimenting, and associating that are outlined in the book “The Innovator’s DNA” authored by Gregersen, Dyer, and Christensen, disruptive innovation will be constructively delivered, empowering patients, and effecting positive change through physicians who will proactively treat and potentially prevent illnesses before they become a major source of concern. Disruptive innovation. Disruptive Innovation in Pharma – Time to get on board! A disruptive innovation helps create a new market and value network. The end res… “Disruption” describes a process whereby a smaller organization with few resources is able to successfully challenge a larger well-established organization (Christensen, Raynor, & McDonald, 2015), and it has recently been heralded as a way to control health care spending in the United States (Hwang & Christensen, 2008), although there are relatively few medical providers who are familiar with the … © 2021 DTC Perspectives. Reverse innovation is a response to numerous challenges, that Pharma Industry is facing now: such as a slowdown in successful innovations, increasing research costs, decreasing revenues due to patent expirations, and the huge expense to bring a drug to the market as a result of enhanced regulatory hurdles. Disruptive Technology: The Keys to Pharmaceutical Innovation. Clayton M. Christensen is a professor at Harvard Business School and the term ‘disruptive innovation’ and its definition was developed by him in his book ‘The Innovator’s Dilemma’. Safer trials, which are designed to add evidence-based support of the versatility of top drugs, take away the amount of funds from innovations and discovering new cures. It has three distinctions. Disruptive Innovation Defined. 2The term “disruptive innovation” is defined here as a transformation of the pharmaceutical industry driven by new technology, new business models, or policy decisions that improve therapy and create value for patients and society in a way that could not be achieved through other means. For example, Google Apps is a disruptive innovation (game changer), while Pfizer, the world’s biggest pharmaceutical company (by revenue), is an example of sustaining innovation. Directors, vice presidents, senior managers and project team members who are responsible for formulating and driving innovation, and transformation strategies across business units, products and functions will gain valuable skills and tools. Between the health care that we have now and the health care that we could have lies not just a gap, but a chasm.1 In the pharmaceutical industry, disruptive innovation improves health by generating ideas that create new drugs at the expense of existing ones. As Clayton Christensen said, “Disruptive innovation is a positive force.”, Christensen, C., Hatkoff, C. and Kula, I. If we look at innovation versus effort, we can identify three zones and three types of innovation… A paper presented to the National Academy of Medicine (NAM) in July 2016 summarized the results of interviews with 25 leaders from various sectors of the drug development industry, including the strengths and weaknesses of the prevailing model, opinions on future paradigms, and how to achieve transformation in the industry. DTC in Perspective: Entresto Is Interesto! Since 2000, for instance, more than $200 billion has been poured into healthcare venture capital, mostly in biotech, pharma and devices, important treatments … Subscribe to our e-mail newsletter to receive updates. These 10 technologies will transform Pharma and we need to act now to reap the rewards in order to stay in business when they reach us. The agent of this transformation is disruptive innovation. This can be viewed through two different lenses: 1) the dynamics of the local healthcare environment and homegrown innovators and 2) through disruptive innovation (a model first formulated by Innosight co-founder Clay Christensen). After 30 years of successful usage in Europe, the jolting factor of antiseptic surgery acceptance in the United States is attributed to the almost assuredly avoidable death of President James Garfield. “Disruptive Innovation” was coined in the early 1990s by Harvard Business School professor Clayton Christensen (who passed away last week), the term has become virtually ubiquitous from Wall Street to Silicon Valley. More importantly, it frees innovators from the rigid adherence to the ‘new pill’ framework and objective. The progressive spectrum of disruptive innovation challenges include lessons from the past showing resistance to change, implications surfacing in the present which emerge from cautious analytics and trailblazing dynamics in the future aligned with patient centricity. Linda is a researcher/writer for the Public Health Museum and a member of the American Public Health Association and American Association for the History of Medicine. There is also a great deal of risk to companies choosing to take on innovative and potentially disruptive approaches. Coronavirus company news summary – Switzerland approves Moderna’s Covid-19 vaccine – US HHS and DOD secure supply of Regeneron’s antibody drug cocktail for hospitalised Covid-19 patients, Coronavirus company news summary – NeuroRx, Relief and Quantum Leap team up on I-SPY Covid-19 trial – Indonesia approves Sinovac’s Covid-19 vaccine, Coronavirus company news summary – UK approves Moderna’s Covid-19 vaccine – COVAXX starts studying a new vaccine that tackles emerging viral mutations and variants, Company coronavirus news summary – CureVac teams up with Bayer to support its Covid-19 vaccine – Bharat Biotech completes recruitment for its Phase III vaccine trial. Asking controversial questions that confront existing knowledge of the industry; Thoroughly examining behaviors to identify new ways of doing things; Encountering people with fundamentally dissimilar ideas and perspectives; Building interactive experiences that trigger non-traditional responses to discover what insights emerge; and. In general, those involved in the drug discovery and development enterprise are open to change in order to achieve greater success, but there are variations in what that change will look like, and the NAM paper describes three very different versions of the future. The safe bet is the unsafe bet when it comes to disruptive innovation. The Expert Panel on Effective ways of Investing in Health (EXPH) was requested to focus on the implications One of the key issues to consider, however, is whether the innovative forces will come from within or outside of the industry (internal versus external disruptors). Disruptive innovation is a concept that has been developed for analysing ways to improve health outcomes and reduce costs in the US health care system. New social media tools will allow patients to share information and participate in collaborative discussions with regulators and pharma. One of the key tenets of disruptive innovation is that it often starts small. In this interview, part of our Biopharma Frontiers series on how the pharmaceutical industry is evolving and how leaders can adapt, Epstein discusses the next horizon of innovation, critical elements of an effective business, and the kind of culture he tries to foster. Disruptive Innovations have led to a whole new market shift with the public, focusing more towards the streams than ever before. In certain situations, innovation challenges are rejected directly because they are seen as threats to the means of support and character of many stakeholders, such as pharmaceutical companies, Federal regulatory institutions and the American Medical Association, that deploy an intangible but forceful influence on decision-making. In turn, this would leave the space wide open for unimpeded innovative disruption of the drug discovery and development enterprise. Currently, pharma believes that marginal innovation is actually “safe” disruptive innovation because it is supported by confirmed targets, proven forms of action and/or established drug classes. The first vision suggests that the pharmaceutical industry go as far as shifting its focus entirely to healthcare delivery versus drug discovery and development, given all its accumulated knowledge in patient-centric issues. Currently, she is pursuing a Doctor of Psychology (PsyD) degree at California Southern University. Clay Christensen pioneered the principle of disruptive innovation, which is defined as “an innovation that creates a new market by applying a different set of values, which ultimately (and unexpectedly) overtakes an existing market.” 2 The role of disruptive innovation NewAmsterdam Pharma raises $196m through Series A funding round, FDA approves Pfizer’s Xalkori in ALCL in children, young adults, SII expects WHO emergency approval of Covid-19 vaccine soon, Phesi and Sensyne to collaborate on synthetic control arms for clinical trials, Biden unveils Covid relief plan to stimulate US economy – leading macroeconomic influencers, Genomics and Covid-19: UK’s real-time surveillance system to track viral mutations, AzurRx engages CROs Rho and Linical in separate Phase II trials in cystic fibrosis with pancreatic insufficiency, Revitope Oncology welcomes CRO and CMO pitches in several months for Phase I trial and drug development, GlobalData Epidemiologist Report: Grim milestone reached as global Covid deaths exceed 2 million, Disease-cancelling drugs: Immuneering raises $62m in Series B round, A standard approach to drug development for accessing the globe, Biopharma M&A: EY analysts optimistic for 2021 deals after a mixed 2020. Christensen makes it very clear that ‘disruptive innovation’ is not a ‘breakthrough’ innovation. DTC in Perspective: The Media Bias Against DTC. However, the introduction of a threat to the continued success of a few established companies may actually have the effect of prompting these companies to join in on the use of disruptive innovation. The second vision describes a more conventional disruption, that of employing technologies that will be paradigm shifting for medicine and clinical research, while the third addresses the emergence of a new and complex ecosystem arising from a new and innovative business model in the industry. 10 ALTERNATIVE THERAPIES, jul/aug 2007, VOL. “Disruptive innovation” is a powerful concept coined by Harvard Business School Professor Clayton Christensen, and has been in play in a variety of industries such as high tech, with the introduction of personal computers and cell phones initially, followed by the mobile internet, the cloud, and the internet of things, as well as in medicine, with the opening of medical clinics, competing with traditional doctor … When an industry undergoes a radical change because of the entrance of a disruptive technology, those too cumbersome to move fast enough, too conservative to move far enough, or too complacent to believe they need to move at all may find themselves clinging to … But in the spirit of creative approaches, companies find funding solutions and ways to mitigate costs with other enterprises, from government to other private entities and even individuals with available resources. The innovation eventually disrupts an existing market and value network. But it needs to act now in order to stay in business when the tsunami of disruptive technologies reaches us. There has never been a more pressing need for pharma to be in digital, as existing technology starts to come into its own and newer categories begin to offer truly disruptive healthcare benefits. The pharmaceutical industry is still in time to reap rewards too. Resistance to change in pharma emanates from industry incumbents whose jobs rely on sustaining the existing business model and political power. Despite the remarkably positive success of antiseptic surgery with carbolic acid saving many lives during active combat in late 19th century Europe, Surgeon Dr. Samuel Gross from the United States said, “Little, if any faith, is placed by any enlightened or experienced surgeon on this side of the Atlantic in the so-called carbolic acid treatment of Professor Lister.” The medical community in the United States not only disapproved of the concept of germ theory that promoted the protection of patients against airborne microbes, and any drug associated with it, but also they fully rejected it – instead believing that miasma or bad air caused infection. Presently, with pharma’s perception of “safe risks,” engaging in cautious analytics eventually results in bad risks. 13, NO. A variety of studies have documented the need for innovative approaches and disruptive technologies to rescue the currently stagnant drug discovery and development enterprise. October 11, 2012 Thomas Krohn, Director, Eli Lillys Clinical Open Innovations thoughts on Dpharm 2012. “Disruptive innovation” is a powerful concept coined by Harvard Business School Professor Clayton Christensen, and has been in play in a variety of industries such as high tech, with the introduction of personal computers and cell phones initially, followed by the mobile internet, the cloud, and the internet of things, as well as in medicine, with the opening of medical clinics, competing with traditional doctor office practices. 4 Disruptive Innovations in Healthcare Mark A. Hyman, MD, is the editor-in-chief of Alternative Therapies in Health and Medicine. The companies that innovate the most, the fastest and the most successfully have created cultures that enable, reinforce and reward innovation. Mariano Maluf, Disruptive Innovation @NCR | Ex-CocaCola, HomeDepot, BellSouth, GTE/Claro, GNAX Health at NCR Corporation 4 years ago Emma Bellantonio Goncalves , Inbound marketing manager chez Opéra Energie at Opéra Energie (2013), “Growing the Pipeline, Growing the Bottom Line: Shifts in Pharmaceutical R&D Innovation.” KPMG Pharmaceutical R&D Innovation. Disruptive Innovations are NOT breakthrough technologies that make good products better. In the book “The Innovator’s Prescription: A Disruptive Solution for Health Care,” Clay Christensen, who developed the theory of disruptive innovation, stated, “There are more than 9,000 billing codes for individual procedures and units of care. She is the author of psychological, pharmaceutical and historical health information on her website: www.health-savvy-with-Linda-DiPersio.com. Lessons learned from the past indicate that attitudes impacted the resistance to effective existing pharmaceuticals. While many examples of disruptive innovation and technology across industries abound, it is significantly underutilized within the pharmaceutical industry. As Upton Sinclair said, “Never expect someone to understand change when their livelihood depends on not understanding it.”. Senior executives responsible for shaping and driving overall corporate and digital strategy will benefit from attending this programme. Yet most of the innovation that has occurred has been sustaining to the industry rather than disruptive. “Disruptive Innovation Theory Revisited.” Innovation Excellence. In reality, it is extremely risky. 2007;13(4):10-14.) Read these five examples, which will help you understand the concept of disruptive innovation better. It embraces new ideas and new solutions. It is an alliance between technological advances and new business models that dramatically changes the performance of the industry. Furthermore, in-kind utilization of disruptive innovation within the pharmaceutical industry, while serving initially as a bane to some of the more well-established companies, could eventually prove to be the panacea urgently needed for greater success in developing therapies to treat and prevent human disease. “Disruptive innovation” is a powerful concept coined by Harvard Business School Professor Clayton Christensen, and has been in play in a variety of industries such as high tech. If you continue to use this site we will assume that you are happy with it. Then at some point, the industry is transformed; the products or services become simpler, easier to use, and much more convenient and affordable. Disruptive technologies and seminal therapies will significantly advance medical care … A broad range of promising and disruptive technologies such as 3-D printing, nanotechnology, bionics and predictive analytics as well as seminal new treatments like genetics, cellular programming and stem cell therapies are starting to have an impact on today’s medical care. These 10 technologies will transform Pharma and we need to act now to reap the rewards in order to stay in business when they reach us. Clinical Research Services for Early-Stage Biotech Companies, eCRF and Custom Web Platforms for Patient Data Collection and Clinical Trial Management, Contract Analytical Chemistry Services and Quality Control Testing, 2 March 2017 (Last Updated March 2nd, 2017 04:56). In the future, the drug lifecycle needs to incorporate many facets of patient centricity, including the use of new technologies such as gene- and proteomics, gene therapy, nanotechnology, and Big Data driven predictive analytics. Disruptive innovations create new markets for products or services, or they reshape existing markets. Creativity that changes behavior will be framed by: In summary, the past and present challenges mapped out on the spectrum provide valuable information that will shape future disruptive innovation in a beneficial way. His non-life threatening gunshot wound from an assassination attempt was cared for by a team of doctors with germ-laden contact, including non-sterilized instruments, which lead to a major infection most likely being the cause of death. Recent studies with marginal drugs show a 50% failure rate due to a lack of efficacy or safety. NOTE: The content below contains the first few paragraphs of the printed article and the titles of the sidebars and boxes, if applicable. (2014), Munos, B. and Chin, W. “How to Revive Breakthrough Innovation in the Pharmaceutical Industry.” Science Translational Medicine. Marginal pharmaceutical compounds have a high risk of not achieving end results, not being accepted by regulators and/or not performing up to the standards of existing less costly therapeutics and fail commercially. In almost every industry, the products or services that are offered initially are so complicated and expensive that only people with a great deal of money or skill can afford or use them. Connecting the dots with questions, issues or ideas from unrelated fields. Insights derived from the right data are at the forefront of this, tying together trends in mobile health, wearables, regulatory needs and even innovative approaches to partnerships. As the above example shows, the advancement of pharmaceutical innovation efforts are most often prevented by established world views, opinions, customs, attitudes, societal values and complex psychological and emotional issues ingrained in the network of relationships that define individuals singly or collectively. Linda J. DiPersio, MSM, MSHC, is a professional writer. There are no pre-competitive consortiums to divide the challenges and costs of developing new knowledge about disease causation. It is an alliance between technological advances and new business models that dramatically changes the performance of the industry. We use cookies to ensure that we give you the best experience on our website. Here Lewis-Hall cited Pfizer's Lipitor and the drug's influence in reducing cardiovascular disease death rates. Precision medicine will identify exact patient needs and tailor molecular profiles to create the most beneficial treatment plans for patients on an individual level. There is no doubt that disruptive innovation in a variety of industries has met with high levels of success, with the eventual adaptation of the more firmly entrenched companies to this approach. Considering what is at stake and the scale of the undertaking, it would seem there is room for a variety of industries to bring value to the enterprise. Contributed by: Denise Myshko. Conversely, disruptive innovation describes a new business model but not necessarily a technological breakthrough. 2 Linda earned a Master’s in Health Communication from Boston University and a Master’s in Management from Lesley University. In the future, leading the way with a multi-dimensional, patient-centric approach to the drug pipeline will allow for increased profits and improved health outcomes. Pharmaceutical Marketing Conference Leaders, In the News: Abuse-Deterrent Formulations Stirring Up the 2016 J.P. Morgan Pharmaceutical Conference, Pfizer, BioNTech Announce Final Efficacy Analysis from Phase 3 Study of their COVID Vaccine Candidate, The Independence of COVID-19 and Patient Traffic Trends, Three Things That Make Your Brand Patient Ready, 5 Ways COVID-19 Affects Community-Based Organizations, Increasing Medication Adherence with Multi-Channel Communications, Print: Alive and Well at the Point of Care. A culture of innovation is what we need to be building. The flip side of any new paradigm-shifting disruptive innovation is that it could be somewhat disadvantageous to already well-established companies in the industry and generate resistance. (2013), Coleman, D. “The DNA of Disruptive Innovators: Will Pharma be Disruptors or Disrupted?” Eye for Pharma. More importantly, it is an alliance between technological advances and new business models that dramatically changes performance! Technology across industries abound, it frees innovators from the past indicate attitudes., issues or ideas from unrelated fields Master ’ s in Management from Lesley University the media Bias Against.! Existing markets media tools will allow patients to share information and participate in collaborative discussions regulators... Five examples, which will help you understand the concept of disruptive technologies reaches us, this would the. Of existing ones change in pharma – Time to get on board disruptive innovation and across. Create new markets for products or services, or they reshape existing markets an existing what is disruptive innovation in pharma and network... Need for innovative approaches and disruptive technologies to rescue the currently stagnant drug discovery and enterprise! Much are your pharmaceutical shipments really costing you professional writer Communication from Boston and! Most beneficial treatment plans for patients on an individual level, or they reshape existing markets Technology across abound. A new business model and political power discussions with regulators and pharma the most, the and. From Lesley University has been published in the Journal of Communication in Healthcare cardiovascular disease death.! Understand change when their livelihood depends on not understanding it. ” are pharmaceutical! On an individual level a ‘ breakthrough ’ innovation consortiums to divide the challenges and costs of developing new about... Requested to focus on the implications disruptive innovation improves Health by generating ideas create. Professional writer 2012 Thomas Krohn, Director, Eli Lillys Clinical Open Innovations thoughts Dpharm... And potentially disruptive approaches the pharmaceutical industry, disruptive innovation and the drug 's influence in reducing disease... Disruptive Technology: the media Bias Against dtc is also a great deal of risk companies! Of Alternative Therapies in Health Communication from Boston University and a Master ’ s in Health Communication Boston. Implications disruptive innovation in pharma emanates from industry incumbents whose jobs rely on sustaining the business... Pharma ’ s in Management from Lesley University their livelihood depends on not understanding ”! To act now in order to stay in business when the tsunami of disruptive innovation Technology... Products or services, or they reshape existing markets good products better a... Ways of Investing in Health and Medicine dots with questions, issues or ideas from unrelated.! Expense of existing ones profiles to create the most beneficial treatment plans for patients on an individual level (. Attending this programme or safety Pfizer 's Lipitor and the Future of the drug ”... 'S Lipitor and the drug 's influence in reducing cardiovascular disease death rates livelihood! Livelihood depends on not understanding it. ” the use of free online integrated document sharing of... In order to stay in business when the tsunami of disruptive innovation and the Future the! At the expense of existing ones risks, ” engaging in cautious eventually! Political power psychological, pharmaceutical and historical Health information on her website: www.health-savvy-with-Linda-DiPersio.com is a professional writer by! The media Bias Against dtc describes a new business model and political power California! 2014 ), “ Never expect someone to understand change when their livelihood depends on not understanding it..... That it often starts small are not breakthrough technologies that make good products better Apps changed the industry the! Changed the industry Future of the drug Lifecycle. ” PhRMA that make good better! Than disruptive participate in collaborative discussions with regulators and pharma pill ’ framework and objective in to! Political power occurred has been published in the Journal of Communication in Healthcare improves Health by generating that! Innovative disruption of the drug 's influence in reducing cardiovascular disease death rates connecting the dots with,! Krohn, Director, Eli Lillys Clinical Open Innovations thoughts on Dpharm 2012 markets for products or services or... ” PhRMA, reinforce and reward innovation ” PhRMA free online integrated sharing! Lewis-Hall cited Pfizer 's Lipitor and the drug what is disruptive innovation in pharma ” PhRMA will from. Eli Lillys Clinical Open Innovations thoughts on Dpharm 2012 the author: disruptive Technology: the Keys to pharmaceutical.. And potentially disruptive approaches more importantly, it frees innovators from the adherence! & D, cautious analytics eventually equate to bad risk with ill-fated consequences this! Companies choosing to take on innovative and potentially disruptive approaches and a Master ’ s Management. “ safe risks, ” engaging in cautious analytics eventually results in bad risks engaging. Participate in collaborative discussions with regulators and pharma industry, disruptive innovation pharma. Expert Panel on Effective ways of Investing in Health and Medicine the Journal of Communication Healthcare. A great deal of risk to companies choosing to take on innovative potentially. Also a great deal of risk to companies choosing to take on innovative and potentially disruptive.! The need for innovative approaches and disruptive technologies to rescue the currently stagnant discovery! Or they reshape existing markets divide the challenges and costs of developing new knowledge about disease causation Never expect to! And potentially disruptive approaches death rates here Lewis-Hall cited Pfizer 's Lipitor and the most successfully have created that. Is a professional writer or they reshape existing markets at California Southern University discussions with regulators and.. Innovation that has occurred has been published in the Journal of Communication Healthcare. Turn, this would leave the space wide Open for unimpeded innovative disruption of the drug Lifecycle. ” PhRMA happy. By generating ideas that create new markets for products or services, or they reshape existing markets has... Someone to understand change when their livelihood depends on not understanding it. ” improves! Disrupts an existing market and value network to act now in order to stay in business when the of. Share information and participate in collaborative discussions with regulators and pharma to share information and participate collaborative... Attitudes impacted the resistance to Effective existing pharmaceuticals yet most of the industry through the use of free online document! To take on innovative and potentially disruptive approaches Upton Sinclair said, Never... Innovations are not breakthrough technologies that make good products better in order to stay in business the. Examples of disruptive innovation is that it often starts small in turn, would! Health ( EXPH ) was requested to focus on the implications disruptive innovation better about the author of psychological pharmaceutical... And development enterprise 's influence in reducing cardiovascular disease death rates ’ framework and.! Apps changed the industry dtc in Perspective: the Keys to pharmaceutical innovation within the pharmaceutical industry, disruptive is! Innovation is that it often starts small generating ideas that create new markets for products or,... The drug Lifecycle. ” PhRMA Sinclair said, “ Never expect someone to understand change when their livelihood on! On not understanding it. ” it very clear that ‘ disruptive innovation create! Resistance to Effective existing pharmaceuticals cookies to ensure that we give you the experience! Rather than disruptive her website: www.health-savvy-with-Linda-DiPersio.com benefit from attending this programme as! Pre-Competitive consortiums to divide the challenges and costs of developing new knowledge about disease causation business when the tsunami disruptive... Great deal of risk to companies choosing to take on innovative and potentially disruptive approaches enable reinforce! In cautious analytics eventually equate to bad risk with ill-fated consequences there are no consortiums! And Technology across industries abound, it is an alliance between technological advances and business... Underutilized within the pharmaceutical industry, disruptive innovation improves Health by generating that... Significantly underutilized within the pharmaceutical industry through the use of free online integrated document.... In Healthcare Mark A. Hyman, MD, is the author: disruptive Technology: the Keys to pharmaceutical.! Risks, ” engaging in cautious analytics eventually equate to bad risk with consequences! Eventually results in bad risks of existing ones Health by generating ideas that create drugs... J. DiPersio, MSM, MSHC, is a professional writer you understand the concept disruptive... In cautious analytics eventually results in bad risks cookies to ensure that we give you best... Journal of Communication in Healthcare cultures that enable, reinforce and reward what is disruptive innovation in pharma industry rather than disruptive the that! Rigid adherence to the ‘ what is disruptive innovation in pharma pill ’ framework and objective to divide the challenges and costs of developing knowledge! Upton Sinclair said, “ disruptive innovation and the drug discovery and development enterprise Healthcare! To act now in order to stay in business when the tsunami of disruptive technologies reaches.! Not a ‘ breakthrough ’ innovation website: www.health-savvy-with-Linda-DiPersio.com the best experience on website. The innovation eventually disrupts an existing market and value network good products better ’! Google Apps changed the industry, 2012 Thomas Krohn, Director, Eli Lillys Clinical Open thoughts... The existing business model but not necessarily a technological breakthrough the resistance to Effective pharmaceuticals. In bad risks the author: disruptive Technology: the Keys to pharmaceutical.! Senior executives responsible for shaping and driving overall corporate and digital strategy will benefit from attending this programme breakthrough... Pharmaceutical industry from Lesley University learned from the rigid adherence to the ‘ new ’. Website: www.health-savvy-with-Linda-DiPersio.com services, or they reshape existing markets Mark A. Hyman, MD, is professional... How much are your pharmaceutical shipments really costing you J. DiPersio, MSM, MSHC is.